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Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 33-40 doi: 10.1007/s11684-016-0431-5

Abstract:

Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increasedPrevious studies focused on cancer cells, but an increasing number of recent studies have analyzed thecontribution of cancer microenvironment to the initiation and progression of breast cancer.Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various activealso serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer.

Keywords： cancer-associated fibroblast     breast cancer     progression     prognosis    

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FGF23 associated bone diseases

Eryuan Liao

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 65-80 doi: 10.1007/s11684-013-0254-6

Abstract:

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential

Keywords： fibroblast growth factor 23     FGF receptor     phosphate metabolism     Klotho     bone disease    

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Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 667-677 doi: 10.1007/s11684-017-0583-y

Abstract: For example, platelets have been shown to protect circulating cancer cells in blood circulation and toIn-depth understanding of the role of platelets in cancer progression and metastasis provides promisingplatelet biomimetic drug delivery systems and functional platelet-targeting strategies for effective cancerrecent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associatedplatelets for cancer therapy.

Keywords： platelet-mimicking delivery systems     tumor-associated platelets     cancer therapy     EPR effect    

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Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 158-163 doi: 10.1007/s11684-009-0042-5

Abstract: The regulatory effect of basic fibroblast growth factor (bFGF) mediated by recombinant adeno-associated

Keywords： tetracycline regulatory system     adeno-associated virus     basic fibroblast growth factor     gene regulation    

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Functional XPF polymorphisms associated with lung cancer susceptibility in a Chinese population

Dian-Ke YU PhD, Chen WU MD, Wen TAN MD, Dong-Xin LIN MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 82-89 doi: 10.1007/s11684-010-0014-9

Abstract: Variation of individuals’ DNA repair capacity has been linked to cancer susceptibility.was to examine the functional significance of promoter polymorphisms and their association with lung cancerfunction of promoter polymorphisms was tested by a set of biochemical assays, and their effects on lung cancerrisk were determined by a case-control analysis of 988 patients with lung cancer and 986 controls.The −673TT genotype was associated with a decreased risk of lung cancer compared with the CC genotype

Keywords： XPF     polymorphism     lung cancer    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsHowever, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associatedSome unsolved challenges, however really engrossing issues, such as the association between irAEs and cancer

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgeryfor head and neck cancer

Yutao Liu, Yaxia Di, Shuai Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 239-246 doi: 10.1007/s11684-017-0509-8

Abstract:

Patients undergoing major oncological surgery for head and neck cancer (SHNC) have a particularlyWe aimed to identify risk factors for ventilator-associated pneumonia (VAP) in patients undergoing SHNC

Keywords： ventilator-associated pneumonia (VAP)     pneumonia     risk factors     surgery for head and neck cancer (SHNC)    

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Potential of electron transfer and its application in dictating routes of biochemical processes associated

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 679-692 doi: 10.1007/s11684-021-0866-1

Abstract: addiction to glutamine, and increased de-novo lipid synthesis, extensively occurs in proliferating cancerenforced selective reprogramming could be predicted by examining the net changes of the PET values associatedSome interesting properties of PET in cancer cells were also discussed, and the model was extended toEnabling electron transfer could drive metabolic reprogramming in cancer metabolism.

Keywords： metabolic reprogramming     potential of electron transfer     cell proliferation     aerobic glycolysis     cancer    

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Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 461-470 doi: 10.1007/s11684-019-0695-7

Abstract: The gut microbiota plays an important role in the development and progression of colorectal cancer (CRC

Keywords： colorectal cancer (CRC)     gut microbiota     intestinal     Eubacterium     Devosia    

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Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 178-182 doi: 10.1007/s11684-016-0442-2

Abstract:

Metastasis-associated gene 1 (MTA1) controls a series of biological processes in tumor progressionThe global cancer gene regulatory network must be analyzed to determine the position of MTA1 in the molecularResults showed that in the development of colon cancer, MTA1 is linked to certain signal pathways, such

Keywords： metastasis-associated gene 1     colon cancer     bioinformatics    

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Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 262-272 doi: 10.1007/s11684-019-0717-5

Abstract: of these cells, such as basal cells, broncho-alveolar stem cells, and alveolar type 2 cells, rely on fibroblast

Keywords： FGF     human lung     repair     regeneration     stem cells    

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Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy Article

Huifang Wu, Dan Hu, Quanxiao Li, Chunyu Wang, Xiaoyi Zhu, Wei Li, Binfan Chen, Ping Ji, Keke Huang, Ailing Huang, Jinghe Huang, Dimiter S. Dimitrov, Yanling Wu, Tianlei Ying

Engineering 2023, Volume 21, Issue 2,   Pages 203-213 doi: 10.1016/j.eng.2022.02.009

Abstract: soluble monomeric immunoglobulin G 1 (IgG1) fragment crystallizable (sFc) or Fc region of IgG in adeno-associatedIt was demonstrated that extending the half-life of a small-sized bifunctional protein and fibroblast

Keywords： Gene therapy     Adeno-associated virus     Half-life     Fibroblast growth factor 21     Type 2 diabetes mellitus    

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Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 323-331 doi: 10.1007/s11684-008-0062-6

Abstract: Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has been

Keywords： Contraction stimulation     phosphatase-proline     molecular structure     discovered     hypertension    

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associatedMoreover, these glycoforms have been associated with various types of cancers, including prostate, breast

Keywords： cancer immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation    

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Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 459-466 doi: 10.1007/s11684-021-0841-x

Abstract: are predisposed to bone marrow failure and hematologic neoplasm is a crucial but unsettled issue in cancer

Keywords： Fanconi anemia     aplastic anemia     hematologic malignancy     germline predisposition    

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Title Author Date Type Operation

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Journal Article

FGF23 associated bone diseases

Eryuan Liao

Journal Article

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Journal Article

Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Journal Article

Functional XPF polymorphisms associated with lung cancer susceptibility in a Chinese population

Dian-Ke YU PhD, Chen WU MD, Wen TAN MD, Dong-Xin LIN MD,

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgeryfor head and neck cancer

Yutao Liu, Yaxia Di, Shuai Fu

Journal Article

Potential of electron transfer and its application in dictating routes of biochemical processes associated

Journal Article

Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Journal Article

Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Journal Article

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

Journal Article

Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy

Huifang Wu, Dan Hu, Quanxiao Li, Chunyu Wang, Xiaoyi Zhu, Wei Li, Binfan Chen, Ping Ji, Keke Huang, Ailing Huang, Jinghe Huang, Dimiter S. Dimitrov, Yanling Wu, Tianlei Ying

Journal Article

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Journal Article

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Journal Article

Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Journal Article